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But 4-AcO was patented after which largely neglected, till it reappeared inside the 1990s rave scene as a fresh designer drug. Then in 1999, professor and psychedelic scientist David E. Nichols tried to place it over the map as a safe and cost-efficient alternate to psilocybin, as it’s a lot easier (and more affordable) to synthesize.MDMA - 4-AcO

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